The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
Mean peak plasma clobetasol propionate concentrations of nanograms/ml occurred in one study eight hours after the second application (13 h after an initial application) of 30 g clobetasol propionate % ointment to normal individuals with healthy skin. Following the application of a second dose of 30 g clobetasol propionate cream %, mean peak plasma concentrations were slightly higher than the ointment and occurred 10 h after application. In a separate study, mean peak plasma concentrations of approximately nanograms/ml and nanograms/ml occurred respectively in patients with psoriasis and eczema three hours after a single application of 25 g clobetasol propionate % ointment.
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