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This is the case in humans as well; sex hormone levels in male and female fetuses and infants differ, and both androgen receptors and estrogen receptors have been identified in brains. Several sex-specific genes not dependent on sex steroids are expressed differently in male and female human brains. Structural sex differences begin to be recognizable by 2 years of age, and in adult men and women include size and shape of corpus callosum (larger in women) and fasciculae connecting each hemisphere internally (larger in men), certain hypothalamic nuclei, and the gonadotropin feedback response to estradiol . [ citation needed ]

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