However, it should be noted that stacking Trenbolone Base with Methenolone / Primobolan, Drostanolone / Masteron or Anavar / Oxandrolone will not be as effective, but Tren is versatile enough to accomodate these. Although some argue these combinations fail to provide better results compared to the use of Trenbolone Base by itself. Competitive bodybuilders commonly use Deca Durabolin for three months, Trenbolone Base for two months and testosterone for five months. Others stack Trenbolone Base with Dianabol, Sustanon / Testosterone Max, Clen-B / Clenbuterol, Winstrol and Anadrol for heightened results.
After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .