Propionates wikipedia

Testosterone is significantly correlated with aggression and competitive behaviour and is directly facilitated by the latter. There are two theories on the role of testosterone in aggression and competition. [78] The first one is the challenge hypothesis which states that testosterone would increase during puberty thus facilitating reproductive and competitive behaviour which would include aggression. [78] Thus it is the challenge of competition among males of the species that facilitates aggression and violence. [78] Studies conducted have found direct correlation between testosterone and dominance especially among the most violent criminals in prison who had the highest testosterone levels. [78] The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males. [78]

Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen , estrogen , or mineralocorticoid receptors , thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (. mast cell , eosinophil , neutrophil , macrophages , and lymphocytes ) and mediators (. histamine , eicosanoids , leukotrienes , and cytokines ) involved in inflammation . Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability .

Drostanolone propionate is a prodrug of drostanolone . [1] Like other AAS, drostanolone is an agonist of the androgen receptor (AR). [1] It is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic activity. [1] As a DHT derivative, drostanolone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites . [1] While no data are available on the progestogenic activity of drostanolone, it is thought to have low or no such activity similarly to other DHT derivatives. [1] Since the drug is not 17α-alkylated , it is not known to cause hepatotoxicity . [1]

Phenazone ( INN and BAN ; also known as phenazon , antipyrine ( USAN ), or analgesine ) is an analgesic , a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic . It was first synthesized by Ludwig Knorr in 1887. [1] [2] : 26–27 Phenazone is synthesized [3] by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone [4] with dimethyl sulfate or methyl iodide . It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours. [5] Indication: Used to relieve pain and fever. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. [6]

Propionates wikipedia

propionates wikipedia

Phenazone ( INN and BAN ; also known as phenazon , antipyrine ( USAN ), or analgesine ) is an analgesic , a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic . It was first synthesized by Ludwig Knorr in 1887. [1] [2] : 26–27 Phenazone is synthesized [3] by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone [4] with dimethyl sulfate or methyl iodide . It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours. [5] Indication: Used to relieve pain and fever. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. [6]

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