Any number of additive trials can be performed. Some additives have specific effects to watch out for – such as ribonucleotides (E627, E631, E635) which tend to cause rashes (“ribo rash”), or aspartame (E951) which tends to have MSG-like effects and cause depression. Additives not on the problem list are less likely to be problematic, however some other additives not in this list have been shown to have adverse effects on people. Splenda (sucralose, E955) can cause rashes especially in the chlorine sensitive, and sugar alcohols or polyols (E420, E421, E953, E965-E968, E1100) tend to cause digestive distress.
Functions of sugar . Sugar is not considered an essential ingredient in bread baking. This is because flour contains a small amount of natural sugars and some starch is converted to sugar during the fermentation process. It does have many important of the added sugar is converted to carbon dioxide and alcohol by the yeast enzymes. It provides necessary sweetness, helps to produce a golden brown color of the crust, improves the textureof the crumb, helps to retain moisture in the crumb and adds to the nutritional value of the bread. High percentage of sugar as used in sweet doughs and Danish pastry doughs retard yeast is the reason why when increasing the percentage of sugar in doughs, the percentage of yeast must be increased by the same proportion.
In 2010 Danish researchers linked the consumption of artificially sweetened, but not sugar-sweetened, soft drinks to preterm delivery of babies. Though the study couldn't distinguish between the various artificial sweeteners, aspartame and acesulfame-potassium are the most widely-used. The authors suggested that the cause of the problem might be the methanol released when aspartame breaks down in the container or in the body. More research is needed on this issue. In the meantime, pregnant women might want to make a special effort to avoid consuming artificial sweeteners.